Biphenomycin biosynthetic pathway decoded, opening door to new antibiotic development

Biphenomycins, natural products derived from bacteria, show excellent antimicrobial activity, but have long remained out of ...

IDEAYA Biosciences Announces IND Submission for IDE574, a Potential First-In-Class KAT6/7 Dual Inhibitor for Breast and Lung Cancers

IDEAYA Biosciences, Inc. (Nasdaq: IDYA), a leading precision medicine oncology company, announced the submission of an ...
BMJ Open

Real-world safety profile of novel anti-multidrug-resistant tuberculosis drugs: a disproportionality analysis based on the FAERS database

Objectives Bedaquiline (BDQ), delamanid (DLM) and pretomanid (Pa) were widely used in recent years. This study aimed to analyse adverse drug event (ADE) reports associated with them based on the Food ...

Mitochondrial enzyme's atomic-level structure reveals how it processes RNA

Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have captured the first detailed molecular ...
Science Daily

Single enzyme mutation reveals a hidden trigger in dementia

Researchers discovered that a tiny structural feature of the enzyme GPX4 helps keep neurons safe. A rare mutation removes ...
Iowa State University News Service

Startup develops new nanosensors to track chemical reactions in ‘the age of enzymes’

That’s the big idea behind Zymosense, “The Nanoassay Company,” a startup that’s spinning off technology developed in the lab ...
eLife

Cardenolide toxin diversity impacts monarch butterfly growth and sequestration

This important study shows that different forms and mixtures of cardenolide toxins in tropical milkweed, especially nitrogen- and sulfur-containing types, change how monarch caterpillars eat, grow, ...