Nature

SPLICER: a highly efficient base editing toolbox that enables in vivo therapeutic exon skipping

Exon skipping technologies enable exclusion of targeted exons from mature mRNA transcripts, which have broad applications in medicine and biotechnology. Existing techniques including antisense ...
WGHP

Exon 20: What You Need to Know About this Rare Form of Lung Cancer

CHICAGO, March 13, 2023 /PRNewswire/ -- Lung cancer is the leading cause of cancer deaths in the United States, but advancements in research and treatment are leading to improved survival rates. The ...
EurekAlert!

Poziotinib is active in EGFR exon 20 mutant non-small cell lung cancer with efficacy highly dependent on insertion location

HOUSTON ― A Phase II clinical trial of poziotinib for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 mutations, led by researchers at The University of Texas ...
ascopubs.org

Identification of Recurrent Insertions and Deletions in Exon 18 and 19 of Human Epidermal Growth Factor Receptor 2 as Potential Drivers in Non–Small-Cell Lung Cancer and ...

Plasma Cell-Free DNA Integrity Assessed by Automated Electrophoresis Predicts the Achievement of Pathologic Complete Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer Patients with ...
Nature

Phylogenomic profile of exon-intron organization across angiosperms, their relationships with protein domains, and functional implications

Eukaryotic genes usually encode proteins and contain exons in different size, including micro and small exon categories. However, genome-wide gene exon-intron organizations and their conservation ...