Researchers tested experimental PCAI compounds against pancreatic cancer cells and found they had powerful anticancer effects. One leading compound blocked more than 90% of cancer cell migration, ...
Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory systems are disrupted, cells can acquire the ability to grow uncontrollably ...
A novel study has found that obesity is associated with a distinct molecular program driving the transition from early-stage, ...
Cancer drug resistance is the devastating reason that treatments fail and cancers metastasize, spreading to distant sites seeding new resistant tumors elsewhere in the body. Combating the problem has ...
Gene expression is finely controlled by the abundance and activation status of transcription factors and their regulators, as well as by a number of reversible modifications of DNA and histones that ...
Panel A summarizes the conventional model of how oncogenic RAS guanosine triphosphatases (i.e., Kirsten rat sarcoma viral oncogene homologue [KRAS], neuroblastoma RAS viral oncogene homologue [NRAS], ...
Endoplasmic reticulum (ER) stress is a key cellular mechanism that is important in the development of many diseases, including cancer. Since the discovery of the unfolded protein response (UPR), ...
A comparative study of dosage strategies in HIPEC: BSA-based vs fixed dose methods.
Mitochondrial defects are associated with the development of diseases such as type 2 diabetes (T2D). Studies in mice and in human tissues, by researchers at the University of Michigan, have now found ...
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a cell surface receptor protein called TIE2 as the missing link between two key signaling pathways that ...
Preclinical research across multiple cancer types now shows that the NAD+ salvage pathway, the same biological mechanism targeted by popular anti-aging supplements like nicotinamide mononucleotide ...
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